Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 43, Issue -, Pages 62-69Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2016.09.003
Keywords
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Funding
- Genome Canada, Genome BC
- Genome Alberta for operations and technology development [205MET and 7203, 215MET and MC3T]
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Matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a robust tool for spatially resolved analysis of biomolecules in situ. Recent advances in high ionization-efficiency MALDI matrices, new matrix deposition procedures, and the development of high spatial-resolution and high sensitivity MS instruments continue to drive new applications of MALDI-MSI, along with other MSI techniques, which allow us to visualize and determine the regio-specific and temporal changes in proteins, peptides, lipids, drug molecules, and metabolites within the tissues, cells and microorganisms. These provide researchers with a new route to the discovery of potential biomarkers of human disease and elucidation of the underlying biology of metabolic regulation, thus bringing our understanding of human health to a new level.
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