Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 42, Issue -, Pages 136-146Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2017.01.004
Keywords
-
Categories
Funding
- National Sciences and Engineering Research Council of Canada (NSERC)
- NSERC PGS scholarship
Ask authors/readers for more resources
Aggregation can be thought of as a form of protein folding in which intermolecular associations lead to the formation of large, insoluble assemblies. Various types of aggregates can be differentiated by their internal structures and gross morphologies (e.g., fibrillar or amorphous), and the ability to accurately predict the likelihood of their formation by a given polypeptide is of great practical utility in the fields of biology (including the study of disease), biotechnology, and biomaterials research. Here we review aggregation/solubility prediction methods and selected applications thereof. The development of increasingly sophisticated methods that incorporate knowledge of conformations possibly adopted by aggregating polypeptide monomers and predict the internal structure of aggregates is improving the accuracy of the predictions and continually expanding the range of applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available