Journal
CLINICAL NUTRITION
Volume 36, Issue 1, Pages 85-92Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2015.11.011
Keywords
Type 2 diabetes; Gut microbiota; Probiotics; Inflammation; Stress oxidative; SCFA
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Funding
- Brazilian Agricultural Research Corporation (EMBRAPA) and Foundation
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Background & aims: Type 2 diabetes has been associated with dysbiosis and one of the possible routes to restore a healthy gut microbiota is by the regular ingestion of probiotics. We aimed to investigate the effects of probiotics on glycemic control, lipid profile, inflammation, oxidative stress and short chain fatty acids in T2D. Methods: In a double-blind, randomized, placebo-controlled trial, 50 volunteers consumed daily 120 g/d of fermented milk for 6 wk. Participants were assigned into two groups: probiotic group, consuming fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis subsp lactis BB-12(10(9) colony-forming units/d, each) and control group, consuming conventional fermented milk. Anthropometric measurements, body composition, fasting blood and faecal samples were taken at baseline and after 6 wk. Results: 45 subjects out of 50 (90%) completed follow-up. After 6 wk, there was a significant decrease in fructosamine levels (-9.91 mmol/L; p = 0.04) and hemoglobin A(1)c tended to be lower (-0.67%; p = 0.06) in probiotic group. TNF-alpha and resistin were significantly reduced in probiotic and control groups (-1.5 and -1.3 pg/mL,-.1 and -2.8 ng/mL, respectively), while IL-10 was significantly reduced (-0.65 pg/mL; p < 0.001) only in the control group. Fecal acetic acid was increased in both groups (0.58 and 0.59% in probiotic and control groups, respectively; p < 0.01). There was a significant difference between groups concerning mean changes of HbA(1c) (+031 for control group vs -0.65 for probiotic group; p = 0.02), total cholesterol (+0.55 for control group vs -0.15 for probiotic group; p = 0.04) and LDL-cholesterol (+0.36 for control group vs -0.20 for probiotic group p = 0.03). Conclusions: Probiotic consumption improved the glycemic control in T2D subjects, however, the intake of fermented milk seems to be involved with others metabolic changes, such as decrease in inflammatory cytokines (TNF-alpha and resistin) and increase in the acetic acid. (C) 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
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