Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 36, Issue -, Pages 64-69Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2017.01.001
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Funding
- UK Natural Environment Research Council [NE/J017442/1]
- Thermo Fisher Scientific (CASE award)
- Einstein-Mount Sinai Diabetes Research Center Grant [P60DK020541]
- Biotechnology and Biological Sciences Research Council [BB/N023013/1] Funding Source: researchfish
- Natural Environment Research Council [1300242, 1330640, 1233365] Funding Source: researchfish
- BBSRC [BB/N023013/1] Funding Source: UKRI
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The metabolome describes the full complement of the tens to hundreds of thousands of low molecular weight metabolites present within a biological system. Identification of the metabolome is critical for discovering the maximum amount of biochemical knowledge from metabolomics datasets. Yet no exhaustive experimental characterisation of any organismal metabolome has been reported to date, dramatically contrasting with the genome sequencing of thousands of plants, animals and microbes. Here, we review the status of metabolome annotation and describe advances in the analytical methodologies being applied. In part through new international coordination, we conclude that we are now entering a new era of metabolome annotation.
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