Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 44, Issue -, Pages 102-109Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2016.09.002
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Funding
- German Federal Ministry of Education and Research (BMBF) [031 A 099]
- BMBF [FKZ 0316169]
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Self-organization of cells is a fundamental design principle in biology, yet the inherent non-linearity of self-organizing systems often poses significant challenges in deciphering the underlying mechanisms. Here, we discuss recent progress in this respect, focusing on examples from development, regeneration and organoid differentiation. Together, these three paradigms emphasize the active material properties of tissues that result from the functional coupling between individual cells as active units. Further, we discuss the challenge of obtaining reproducible outcomes on the basis of self-organizing systems, which development and regeneration, but not the current organoid culture protocols, achieve.
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