Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 101, Issue 3, Pages 987-1001Publisher
SPRINGER
DOI: 10.1007/s00253-016-8083-6
Keywords
Alcohol dehydrogenases; Biotechnological applications; Chiral pharmaceuticals; Fine chemicals
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Funding
- Research Project of the National Natural Science Foundation of China [21672190]
- Major Program for Key Science and Technology of Zhejiang Province of China [2014C03010]
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Alcohol dehydrogenases (ADHs), which belong to the oxidoreductase superfamily, catalyze the interconversion between alcohols and aldehydes or ketones with high stereoselectivity under mild conditions. ADHs are widely employed as biocatalysts for the dynamic kinetic resolution of racemic substrates and for the preparation of enantiomerically pure chemicals. This review provides an overview of biotechnological applications for ADHs in the production of chiral pharmaceuticals and fine chemicals.
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