Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 359, Issue 4, Pages 534-575Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201601188
Keywords
catalysis; diastereodivergence; diastereo-selectivity; dual catalysis; organocatalysis; transition metals
Categories
Funding
- Welch Foundation [AX-1593]
Ask authors/readers for more resources
Because the biological and/or pharmacological properties of a given molecule often depend on the absolute and relative configurations of the stereogenic centers, different diastereomers may exhibit totally different biological and/or pharmacological activities. Therefore, for compounds containing multiple stereogenic centers, the stereoselective asymmetric synthesis of all of the individual diastereomers, preferably using a catalytic method, is of great interest and importance in organic synthesis and drug discovery. In this context, the development of catalytic diastereodivergent methods is highly desirable, since it provides one of the most efficient ways to access multiple diastereomers from the same substrates. The current review attempts to summarize the developments in the field of asymmetric diastereodivergent catalysis. 1 Introduction 2 Organocatalytic Diastereodivergent Reactions 3 Metal Complex-Catalyzed Diastereodivergent Reactions 4 Dual Catalytic Diastereodivergent Reactions 5 Catalytic Diastereodivergent Reactions with Chiral Starting Materials 6 Pseudo-Diastereodivergent Reactions 7 Summary and Outlook
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available