Cocrystallization of Etodolac: Prediction of Cocrystallization, Synthesis, Solid State Characterization and In Vitro Drug Release

The present investigation deals with determination of Hansen solubility parameters, synthesis and characterization of etodolac co-crystals with various coformers. Various coformers were screened under the study to prepare cocrystals of etodolac for improving its solubility and dissolution. The prepared cocrystals were characterized by saturation solubility study, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), in vitro dissolution studies and stability study. The outcome of study show that the significant improvement in solubility with p-aminobenzoic acid, ferulic acid and salicylic acid. Etodolac: Salicylic acid cocrystal 1:1M were formulated as immediate release tablets. The results reveal that solubility and dissolution of etodolac was improved by cocrystallization and it possesses adequate pharmaceutical stability.