Journal
BIOMATERIALS
Volume 117, Issue -, Pages 54-65Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.11.057
Keywords
Mesoporous silica nanoparticle; Tumor-target; Supramolecular photosensitizer; Dual-modal imaging; Photodynamic/chemo therapy
Funding
- National Natural Science Foundation of China [51233003, 51533006]
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Supramolecular photosensitizers (supraPSs) have emerged as effective photodynamic therapy (PDT) agents. Here, we propose the assembling capacity of supraPSs as a new strategy to construct theranostic nanoplatform with versatile functions aming at high-performance tumor therapy. By coating tirapazamine (TPZ)-loaded mesoporous silica nanoparticles (MSNs) with layer-by-layer (LbL) assembled multilayer, the versatile nanoplatform (TPZ@MCMSN-Gd3+) was obtained with the formation of supraPSs via host-guest interaction and the chelation with paramagnetic Gd3+. The TPZ@MCMSN-Gd3+ could be specifically uptaken by CD44 receptor overexpressed tumor cells and respond to hyaluronidase (HAase) to trigger the release of therapeutics. As confirmed by in vivo studies, TPZ@MCMSN-Gd3+ showed preferential accumulation in tumor site and significantly inhibited the tumor progression by the collaboration of PDT and bioreductive chemotherapy under NIR fluorescence/MR imaging guidance. Taken together, this supraPSs based strategy paves a new paradigm of the way for the construction of theranostic nanoplatform. (C) 2016 Elsevier Ltd. All rights reserved.
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