Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 4, Pages 3266-3271Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b13162
Keywords
supramolecular chemistry; polydopamine; polyphenol; protein; bioinspired materials; sulfate functionalization; biointerfaces; hydrogel
Funding
- EC seventh Framework Programme Marie Curie Actions via the European ITN SMARTNET [316656]
- U.S. Army Research Laboratory
- U.S. Army Research Office [W911NF-16-1-0113]
- Strathclyde Academic Investment Scheme
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Biocatalytic control of molecular self-assembly provides an effective approach for developing smart biomaterials, allowing versatile enzyme-mediated tuning of material structure and properties as well as enabling biomedical applications. We functionalized surfaces with bioinspired polydopamine and polyphenol coatings to study the effects of enzyme surface localization and surface release on the self-assembly process. We show how these coatings could be conveniently used to release enzymes for bulk gelation as well as to irreversibly immobilize enzymes for localizing the self-assembly to the surface. The results provide insights to the mode of action of biocatalytic self-assembly relevant to nanofabrication and enzyme-responsive materials.
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