Journal
CIRCULATION RESEARCH
Volume 120, Issue 4, Pages 736-743Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.116.309692
Keywords
atherosclerosis; coronary artery disease; extracellular trap; neutrophils; thrombosis
Funding
- Deutsche Forschungsgemeinschaft [SFB1123-A1, SFB1123-B5, SFB914-B08, SO876/6-1, SO876/11-1]
- Nederlandse organisatie voor Wetenschappelijk Onderzoek (VIDI) [91712303]
- European Research Council (AdG) [692511 PROVASC]
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Neutrophil extracellular traps expelled from suicidal neutrophils comprise a complex structure of nuclear chromatin and proteins of nuclear, granular, and cytosolic origin. These net-like structures have also been detected in atherosclerotic lesions and arterial thrombi in humans and mice. Functionally, neutrophil extracellular traps have been shown to induce activation of endothelial cells, antigen-presenting cells, and platelets, resulting in a proinflammatory immune response. Overall, this suggests that they are not only present in plaques and thrombi but also they may play a causative role in triggering atherosclerotic plaque formation and arterial thrombosis. This review will focus on current findings of the involvement of neutrophil extracellular traps in atherogenesis and atherothrombosis.
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