4.7 Article

PSMA-targeted contrast agents for intraoperative imaging of prostate cancer

Journal

CHEMICAL COMMUNICATIONS
Volume 53, Issue 10, Pages 1611-1614

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc09781b

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Funding

  1. NIBIB [R01-EB011523, R01-EB017699]
  2. National Natural Science Foundation of China [81502932]

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Prostate-specific membrane antigen (PSMA) can serve as a molecular cell surface target for the detection and treatment of prostate cancer. Near-infrared (NIR) fluorescence imaging enables highly sensitive, rapid, and non-radioactive imaging of PSMA, though specific targeting still remains a challenge because no optimized contrast agents exist.

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