Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 7, Pages 1873-1876Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201610426
Keywords
alkynylation; amino acids; C-H activation; palladium; pyridine
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Funding
- Scripps Research Institute
- NIH (NIGMS) [2R01 GM084019]
- Young Teacher Abroad Training Program of Sichuan University
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The palladium(II)-catalyzed beta-and-alkynylation of amide C(sp(3))-H bonds is enabled by pyridine-based ligands. This alkynylation reaction is compatible with substrates containing alpha-tertiary or alpha-quaternary carbon centers. The beta-methylene C(sp(3))-H bonds of various carbocyclic rings were also successfully alkynylated.
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