Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 11, Pages 1912-1915Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc09933e
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Funding
- BBSRC [BB/J007250/1]
- National Science Foundation of China [31300061]
- BBSRC [BB/J007250/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/J007250/1] Funding Source: researchfish
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Chemical 'chain termination' probes were utilised for the investigation of thiotetronate antibiotic biosynthesis in the filamentous bacteria Lentzea sp. and Streptomyces thiolactonus NRRL 15439. The use of these tools led to the capture of biosynthetic intermediates involved in the thiotetronate polyketide backbone assembly, providing first insights into substrate specificity and in vivo intermediate processing by unusual iterative synthases.
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