Journal
ANALYTICAL CHEMISTRY
Volume 89, Issue 3, Pages 1801-1807Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.6b04114
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Funding
- National Natural Science Foundation of China [21271094]
- Ministry of Science and Technology of China [2014DFA31890]
- National Science Foundation for Fostering Talents in Basic Research of the National Natural Science Foundation of China [J1103307]
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Herein a phenylselenium-substituted BODIPY (1) fluorescent turn-off sensor was developed for the purpose to achieve excellent selectivity and sensitivity for H2S detection based on the substitution reaction of the phenylselenide group at the 3-position with H2S. The excess addition of hydrogen sulfide promoted further substitution of the phenylselenide group at the 5-position of the probe and was accompanied by a further decrease in fluorescence emission intensity. Sensor 1 demonstrated remarkable performance with 49-fold red color fluorescence intensity decrease at longer excitation wavelength, a low detection limit (0.0025 mu M), and specific fluorescent response toward H2S over anions, biothiols, and other amino acids in neutral media. It showed no obvious cell toxicity and good membrane permeability, which was well exploited for intracellular H2S detection and imaging through fluorescence microscopy imaging.
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