Journal
CARBOHYDRATE POLYMERS
Volume 157, Issue -, Pages 629-636Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.10.040
Keywords
Chuanmingshen violacenm polysaccharides; Antioxidant activity; Anti-aging
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Funding
- Foundation of Chengdu University [2015XJZ07]
- National Natural Science Foundation of China [31402238]
- Advanced and Applied Basic Research Program [Nocstc2015jcyjA80023]
- Fundamental Research Funds for the Central Universities [SWU113091]
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The water-soluble polysaccharides were extracted and purified from the root of Chuanminshen violaceum (CVPS). The antioxidant activities of the CVPS were evaluated both with in vitro and in vivo experiments. The results of the in vitro antioxidant assay suggested that the CVPS scavenged DPPH, hydroxyl, and superoxide anion radicals. The oral administration of three different doses of CVPS administered over a period of 6 weeks to D-galactose induced aging mice models, enhanced the activities of T-SOD, Mn-SOD, Cu, Zn-SOD, and CAT, and markedly decreased the content of MDA. Therefore, significant up-regulation of mRNA expression levels of Cu, Zn-SOD, Mn-SOD, CAT, glutathione peroxidase 1 (GPx), thioredoxin 1 (Trx1), and thioredoxin 2 (Trx1) occurred. Finally, the results demonstrated that the CVPS are a novel potential resource for natural antioxidants and anti-aging drugs. (C) 2016 Elsevier Ltd. All rights reserved.
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