Journal
FRONTIERS IN MICROBIOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2017.02546
Keywords
Streptomyces; sigma factor; primary metabolism; secondary metabolism; morphological differentiation; stress response
Categories
Funding
- National Natural Science Foundation of China [31300054]
- Fund of the Natural Science Foundation of Jiangsu Province of China [BK20171163]
- Natural Science Foundation of Xuzhou City [KC15N0014]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Ask authors/readers for more resources
The gram-positive filamentous bacterium Streptomyces is one of the largest resources for bioactive metabolites, particularly antibiotics. Antibiotic production and other metabolic processes are tightly regulated at the transcriptional level. Sigma (s) factors are components of bacterial RNA polymerases that determine promoter specificity. In Streptomyces, s factors also play essential roles in signal transduction and in regulatory networks, thereby assisting in their survival in complex environments. However, our current understanding of s factors in Streptomyces is still limited. In this mini-review, we demonstrate the roles of Streptomyces s factors, illustrating that these serve as linkers of different metabolic pathways. Further investigations on s factors may improve our knowledge of Streptomyces physiology and benefit exploitation of Streptomyces resources.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available