Journal
FRONTIERS IN MICROBIOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2017.00660
Keywords
Listeria monocytogenes; internalin; cell-surface protein; biofilm formation; mucins; bacterial adhesion
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Funding
- National Center of Science [2013/09/B/NZ6/00710]
- CampusFrance Programme Hubert Curien (PHC) France-Poland POLONIUM [28298ZE]
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The bacterial etiological agent of listeriosis, Listeria monocytogenes, is an opportunistic intracellular foodborne pathogen. The infection cycle of L. monocytogenes is well-characterized and involves several key virulence factors, including internalins A and B. While 35 genes encoding internalins have been identified in L. monocytogenes, less than half of themhave been characterized as yet. Focusing on lmo2026, it was shown this gene encodes a class I internalin, InlL, exhibiting domains potentially involved in adhesion. Following a functional genetic approach, InlL was demonstrated to be involved in initial bacterial adhesion as well as sessile development in L. monocytogenes. In addition, InlL enables binding to mucin of type 2, i.e., the main secreted mucin making up the mucus layer, rather than to surface-locatedmucin of type 1. InlL thus appears as a newmolecular determinant contributing to the colonization ability of L. monocytogenes.
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