Journal
FRONTIERS IN MICROBIOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2017.01445
Keywords
cefquinome; Escherichia coli; environmental mastitis; dosage regimen; PK/PD; mouse model
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Funding
- Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China [IRT13063]
- National Key Research and Development Program [2017YFD0501404]
- Natural Science Foundation of Guangdong Province [S2012030006590]
- South China Agricultural University [2017LHPY026]
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This work investigates the pharmacodynamic effectiveness of cefquinome against environmental Escherichia coli mastitis infection, following an intramammary administration. We established the pharmacokinetic and pharmacodynamic (PK/PD) model in lactating mice. The PK/PD parameters were identified to achieve an antibacterial efficacy as indicated by PD activity, cytokine expression and PK/PD simulation. From our findings, given an 200 mu g/gland dose once daily can achieve a considerable therapeutic effectiveness in experimental circumstance.
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