Journal
CELL
Volume 168, Issue 4, Pages 670-691Publisher
CELL PRESS
DOI: 10.1016/j.cell.2016.11.037
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Funding
- American Cancer Society - New England Division - Ellison Foundation Postdoctoral Fellowship [PF-15-131-01-CSM]
- National Health and Medical Research Council of Australia [NHMRC APP1071853]
- K99/R00 Pathway to Independence Award [NIH/NCI 1K99CA201574-01A1]
- NIH [R01-CA078461]
- Breast Cancer Research Foundation
- Advanced Medical Research Foundation
- Ludwig Center for Molecular Oncology
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Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology. As the body of research concerning metastasis continues to grow at a rapid rate, the biological programs that underlie the dissemination and metastatic outgrowth of cancer cells are beginning to come into view. In this review we summarize the cellular and molecular mechanisms involved in metastasis, with a focus on carcinomas where the most is known, and we highlight the general principles of metastasis that have begun to emerge.
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