Journal
CARBOHYDRATE POLYMERS
Volume 157, Issue -, Pages 1538-1547Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.11.040
Keywords
Chitosan; Silver nanoparticles; Bletilla striata polysaccharide; Bilayer; Wound healing
Categories
Funding
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1406402]
- National Science & Technology Support Program of China [2013BAB01B02]
- Taishan scholar project special funds
- Major Science and Technology Projects in Shandong Province [2015ZDJS04002]
- Ocean University of China [OUC 201562031]
- NSFC [31670811, 21602212, 31600646]
- China Postdoctoral Science Foundation [2016M590664]
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The purpose of this study was to develop a promising wound dressing. Though chitosan cross-linked with genipin has been widely used as biomaterials, with the addition of partially oxidized Bletilla striata polysaccharide, the newly developed material in this study (coded as CSGB) showed less gelling time, more uniform aperture distribution, higher water retention, demanded mechanical strength and more L929 cell proliferation compared to the chitosan cross-linked only with genipin. Owning to partial blocking of free amino groups of chitosan, CSGB revealed almost no antibacterial activities, thus the bilayer composite of chitosan-silver nanoparticles (CS-AgG) on CSGB was designed to inhibit microbial invasion. The in vivo studies indicated that both CSGB and bilayer wound dressing significantly accelerated the healing rate of cutaneous wounds in mice, and the bilayer exhibited better mature epidermization with less inflammatory cells on Day 7. Therefore, this novel bilayer composite has great potential in wound dressing applications. (C) 2016 Elsevier Ltd. All rights reserved.
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