Journal
FRONTIERS IN MICROBIOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2017.02171
Keywords
microbiome; metabolite; fatty acid; vitamin
Categories
Funding
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [23229004, 26293111, 16H01373, 17K17686, 17J07480]
- Practical Research Project for Allergic Diseases and Immunology (Research on Allergic Diseases and Immunology)
- Japan Agency for Medical Research and Development (AMED)
- Ministry of Health, Labour and Welfare (MHLW)
- Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries, and Food Industry
- Astellas Foundation for Research on Metabolic Disorders
- Public Health Research Foundation
- Terumo Foundation for Life Science and Arts
- Suzuken Memorial Foundation
- Grants-in-Aid for Scientific Research [16H01373, 26293111, 17J07480, 17K17686] Funding Source: KAKEN
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Mucosal surfaces in the body, especially the intestine, are constantly exposed to trillions of microbiomes. Accumulating evidence has revealed that changes in the composition of the gut microbiome, especially that of the commensal bacteria population, are frequently associated with immunologic disorders. These changes coincide with changes in the production of certain dietary metabolites. Recent studies have uncovered the molecular and cellular mechanisms underlying the relationships among diet, commensal bacteria, and the host immune system. In this review, we describe how dietary and microbial metabolites modulate host immunity.
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