Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 6, Pages 5100-5108Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b14633
Keywords
microvesicles; phospholipid substitution; tumor targeting; synergistic therapy; in vivo imaging
Funding
- National Natural Science Foundation of China [21475099, 21535005]
- Natural Science Foundation of Hubei [2014CFA003]
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As an ideal nanovector candidate, microvesicles (MVs) have been gradually utilized for packaging kinds of functional molecules for effective tumor diagnosis and therapy; however, the deficiency of their tumor targeting influenced their therapy efficacy. Through a facile phospholipid substitution strategy, MVs-based drug delivery system (DDS) was apparently endowed with high tumor targeting toward breast cancer thanks to the modified folate onto the membrane of MVs, simultaneously possessing a synergistic antitumor effect, and in vivo tumor imaging attributed to the SA-QDs labeling. Tumor killing effect could be improved up to 15 percentages with the help of the improved tumor targeting ability.
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