Journal
EXPERIMENTAL BRAIN RESEARCH
Volume 235, Issue 9, Pages 2893-2899Publisher
SPRINGER
DOI: 10.1007/s00221-017-5021-5
Keywords
Social isolation; Anxiety; Depression; Sex difference; Mice
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Funding
- National Natural Science Foundation of China [31200827]
- Shanghai Municipal Commission of Health and Family Planning [20134Y134]
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Effects of post-weaning isolation on depressive- and anxiety-like behaviors in rodents have been well studied in the past. However, few studies included both sexes in a single experiment to study the sex difference in this animal model. The present study investigated the effect of post-weaning isolation on anxiety- and depressive-like behaviors in both male and female C57BL/6 J mice. Mice were individually or grouped housed from postnatal day 21 for 5 weeks until behavioral tests began. The results showed that social isolation resulted in increased anxiety in the open field. Isolated-reared female, but not male mice showed an increased transition between two compartments in the light-dark box and a decreased immobile time in the forced swim test. We conclude that post-weaning isolation has a sex-specific effect on emotional behaviors.
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