Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 14, Pages 2268-2271Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc08492c
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Funding
- European Research Council (ERC) [615879]
- Bill and Melinda Gates Foundation (GCE grant) [OPP1035881, OPP1097238]
- Italian Association for Cancer Research [AIRC grant] [14708]
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Aggregation, red-NIR emission and light-up upon nucleic acid G-quadruplex binding have been investigated for a prototype core-extended naphthalene diimide, which is capable of fast cellular entry and nucleolar localization. Both high-level colocalization with an anti-G-quadruplex antibody and nucleolin displacement reveal that the compound targets and thus makes visible nuclear DNA G-quadruplexes.
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