Journal
CHEMMEDCHEM
Volume 12, Issue 4, Pages 284-287Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201600632
Keywords
diarylethenes; enzyme inhibitors; photoactivation; photochromism; protein kinase C
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Funding
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- Canada Research Chairs Program
- Canada Foundation for Innovation (CFI)
- British Columbia Knowledge Development Fund (BCKDF)
- Simon Fraser University
- Canada Graduate Doctorate Scholarship (NSERC CGS-D)
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A photoresponsive small molecule undergoes a ring-opening reaction when exposed to visible light and becomes an active inhibitor of the enzyme protein kinaseC. This turning on of enzyme inhibition with light puts control into the hands of the user, creating the opportunity to regulate when and where enzyme catalysis takes place.
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