Journal
CANCER LETTERS
Volume 386, Issue -, Pages 189-195Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2016.11.019
Keywords
Osteosarcoma; Bone cancer; Cancer stem cell; Tumour heterogeneity
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Funding
- Bone Cancer Research Trust (UK) [144681]
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Osteosarcoma is the most common primary bone tumour in children and adolescents and advanced osteosarcoma patients with evidence of metastasis share a poor prognosis. Osteosarcoma frequently gains resistance to standard therapies highlighting the need for improved treatment regimens and identification of novel therapeutic targets. Cancer stem cells (CSC) represent a sub-type of tumour cells attributed to critical steps in cancer including tumour propagation, therapy resistance, recurrence and in some cases metastasis. Recent published work demonstrates evidence of cancer stem cell phenotypes in osteosarcoma with links to drug resistance and tumorigenesis. In this review we will discuss the commonly used isolation techniques for cancer stem cells in osteosarcoma as well as the identified biochemical and molecular markers. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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