Journal
ELIFE
Volume 6, Issue -, Pages -Publisher
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.30126
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Funding
- Hong Kong Research Grants Council [RGC GRF 777411, RGC GRF 17113415]
- Swedish Research Council [K2014-64X-20097-09-5]
- Swedish Cancer Society [CAN 2016/271]
- ICMC (Integrated Cardio Metabolic Center)
- NIH RO1 grants [DK064640, DC014718]
- Hong Kong Research Grants Council [RGC GRF 777411, RGC GRF 17113415]
- Swedish Research Council [K2014-64X-20097-09-5]
- Swedish Cancer Society [CAN 2016/271]
- ICMC (Integrated Cardio Metabolic Center)
- NIH RO1 grants [DK064640, DC014718]
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Craniofacial morphogenesis requires proper development of pharyngeal arches and epibranchial placodes. We show that the epibranchial placodes, in addition to giving rise to cranial sensory neurons, generate a novel lineage-related non-neuronal cell population for mouse pharyngeal arch development. Eya1 is essential for the development of epibranchial placodes and proximal pharyngeal arches. We identify an Eya1-Notch regulatory axis that specifies both the neuronal and non-neuronal commitment of the epibranchial placode, where Notch acts downstream of Eya1 and promotes the non-neuronal cell fate. Notch is regulated by the threonine phosphatase activity of Eya1. Eya1 dephosphorylates p-threonine-2122 of the Notch1 intracellular domain (Notch1 ICD), which increases the stability of Notch1 ICD and maintains Notch signaling activity in the non-neuronal epibranchial placodal cells. Our data unveil a more complex differentiation program in epibranchial placodes and an important role for the Eya1-Notch axis in craniofacial morphogenesis.
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