Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 17, Pages 2618-2621Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc08978j
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Funding
- National Natural Science Foundation of China [81571799, 21202147]
- Natural Science Foundation of Zhejiang Province [LY13H090013, LQ14B020003]
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We here provide the first report on the construction of nanoparticles formulating highly potent cytotoxic therapeutics using albumin. Maytansinoid DM1 can be efficiently integrated into albumin nanoparticles, resulting in remarkable alleviation of in vivo drug toxicity and expanding the repertoire of albumin technology available for cancer therapy.
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