Journal
ELIFE
Volume 6, Issue -, Pages -Publisher
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.28527
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Funding
- Japan Society for the Promotion of Science [KAKENHI JP22687004, KAKENHI JP23126517, KAKENHI JP25126717, KAKENHI JP26291066, KAKENHI JP15KK0259, KAKENHI JP25440171, 15J03781]
- Bio-oriented Technology Research Advancement Institution
- Toray Science Foundation
- Mishima Kaiun Memorial Foundation
- Suzuken Memorial Foundation
- Skylark Food Science Institute
- Urakami Foundation for Food and Food Culture Promotion
- Kao Research Council for the Study of Healthcare Science
- Grants-in-Aid for Scientific Research [15J03781, 15KK0259, 26291066] Funding Source: KAKEN
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Mechanisms underlying the central regulation of food intake and fat accumulation are not fully understood. We found that neurosecretory protein GL (NPGL), a newly-identified neuropeptide, increased food intake and white adipose tissue (WAT) in rats. NPGL-precursor gene overexpression in the hypothalamus caused increases in food intake, WAT, body mass, and circulating insulin when fed a high calorie diet. Intracerebroventricular administration of NPGL induced de novo lipogenesis in WAT, increased insulin, and it selectively induced carbohydrate intake. Neutralizing antibody administration decreased the size of lipid droplets in WAT. Npgl mRNA expression was upregulated by fasting and low insulin levels. Additionally, NPGL-producing cells were responsive to insulin. These results point to NPGL as a novel neuronal regulator that drives food intake and fat deposition through de novo lipogenesis and acts to maintain steadystate fat level in concert with insulin. Dysregulation of NPGL may be a root cause of obesity.
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