Journal
ELIFE
Volume 6, Issue -, Pages -Publisher
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.23882
Keywords
-
Categories
Funding
- Higher Education Commission, Pakistan
- UK Hereditary Spastic Paraplegia Support Group
- Motor Neurone Disease Association [861-792]
- European Commission [220874, 220851, 236777, 660516]
- Agency for Science, Technology and Research [BM/RES/07/005]
- Wellcome [08136]
- Biotechnology and Biological Sciences Research Council [BB/LO21706/1]
- Cambridge Commonwealth, European and International Trust
- Yousef Jameel Foundation
- Biotechnology and Biological Sciences Research Council [BB/L021706/1] Funding Source: researchfish
- Motor Neurone Disease Association [OKane/Oct11/861-792, OKane/Oct11/861-792, O Kane/Oct11/861-792] Funding Source: researchfish
- BBSRC [BB/L021706/1] Funding Source: UKRI
- Marie Curie Actions (MSCA) [660516] Funding Source: Marie Curie Actions (MSCA)
Ask authors/readers for more resources
Axons contain a smooth tubular endoplasmic reticulum (ER) network that is thought to be continuous with ER throughout the neuron; the mechanisms that form this axonal network are unknown. Mutations affecting reticulon or REEP proteins, with intramembrane hairpin domains that model ER membranes, cause an axon degenerative disease, hereditary spastic paraplegia (HSP). We show that Drosophila axons have a dynamic axonal ER network, which these proteins help to model. Loss of HSP hairpin proteins causes ER sheet expansion, partial loss of ER from distal motor axons, and occasional discontinuities in axonal ER. Ultrastructural analysis reveals an extensive ER network in axons, which shows larger and fewer tubules in larvae that lack reticulon and REEP proteins, consistent with loss of membrane curvature. Therefore HSP hairpin-containing proteins are required for shaping and continuity of axonal ER, thus suggesting roles for ER modeling in axon maintenance and function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available