Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 617, Issue -, Pages 68-83Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2016.12.003
Keywords
Phospholipid hydroperoxide glutathione peroxidase; Phospholipase A(2); Lysophospholipid acyl transferase; NADPH oxidase; Phospholipid remodeling; Anti-oxidant defense
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Funding
- NHLBI NIH HHS [R01 HL102016] Funding Source: Medline
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Peroxiredoxin 6 represents a widely distributed group of peroxiredoxins that contain a single conserved cysteine in the protein monomer (1-cys Prdx). The cys when oxidized to the sulfenic form is reduced with glutathione (GSH) catalyzed by the pi isoform of GSH-S-transferase. Three enzymatic activities of the protein have been described:1) peroxidase with H2O2, short chain hydroperoxides, and phospholipid hydroperoxides as substrates; 2) phospholipase A(2) (PLA(2)); and 3) lysophosphatidylcholine acyl transferase (LPCAT). These activities have important physiological roles in antioxidant defense, turnover of cellular phospholipids, and the generation of superoxide anion via initiation of the signaling cascade for activation of NADPH oxidase (type 2). The ability of Prdx6 to reduce peroxidized cell membrane phospholipids (peroxidase activity) and also to replace the oxidized sn-2 fatty acyl group through hydrolysis/reacylation (PLA(2) and LPCAT activities) provides a complete system for the repair of peroxidized cell membranes. (C) 2016 Elsevier Inc. All rights reserved.
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