Journal
CELL CALCIUM
Volume 62, Issue -, Pages 1-15Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2017.01.003
Keywords
Calcium (Ca2+); Mitochondria; Endoplasmic reticulum (ER); Inter-organelle contacts; ER-mitochondria tethering; Mitochondria-Associated Membranes; (MAMs); Mitofusin 2
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Funding
- University of Padova
- Italian Ministry of University and Scientific Research
- Fondazione Cassa di Risparmio di Padova e Rovigo
- EU Joint Programme in Neurodegenerative Disease, 2015-2018, Cellular Bioenergetics in Neurodegenerative Diseases: A system-based pathway and target analysis
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The close apposition between endoplasmic reticulum (ER) and mitochondria represents a key platform, capable to regulate different fundamental cellular pathways. Among these, Ca2+ signaling and lipid homeostasis have been demonstrated over the last years to be deeply modulated by ER-mitochondria cross-talk. Given its importance in cell life/death decisions, increasing evidence suggests that alterations of the ER-mitochondria axis could be responsible for the onset and progression of several diseases, including neurodegeneration, cancer and obesity. However, the molecular identity of the proteins controlling this inter-organelle apposition is still debated. In this review, we summarize the main cellular pathways controlled by ER-mitochondria appositions, focusing on the principal molecules reported to be involved in this interplay and on those diseases for which alterations in organelles communication have been reported. (C) 2017 Elsevier Ltd. All rights reserved.
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