Journal
CLINICS IN PERINATOLOGY
Volume 44, Issue 1, Pages 121-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.clp.2016.11.012
Keywords
Cytomegalovirus; Lactation; Native breast milk; Virus reactivation; Short- and long-term outcome; Very low birth weight infants (VLBW); Virus inactivation; Ganciclovir
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Cytomegalovirus (CMV) is reactivated in the lactating breast in up to 96% of CMV seropositive mothers. There is a relevant entity of postnatally acquired symptomatic CMV infection and disease of preterm infants through raw breast milk (BM). Actual data support negative influence on long-term cognitive development. Concerning prevention, only heat inactivation eliminates virus infectivity, and short-term heat inactivation is most preservative; this can be applied effectively under routine conditions. Short-term heat inactivation for 5 minutes at 62 degrees C maintains the benefits of feeding BM without the disadvantages of CMV transmission.
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