Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 10, Pages 2619-2622Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201611446
Keywords
amyotrophic lateral sclerosis; angiogenesis; prodrugs; reactive oxygen species; ribonuclease
Categories
Funding
- Advanced Opportunity/Graduate Research Scholar Fellowship
- Molecular Biosciences Training Grant from the National Institutes of Health (NIH) [T32 GM007215]
- NIH [R01 CA073808, R01 GM044786, P41 GM103399]
Ask authors/readers for more resources
Angiogenin (ANG) is a human ribonuclease that is compromised in patients with amyotrophic lateral sclerosis (ALS). ANG also promotes neovascularization, and can induce hemorrhage and encourage tumor growth. The causal neurodegeneration of ALS is associated with reactive oxygen species, which are also known to elicit the oxidative cleavage of carbon-boron bonds. We have developed a synthetic boronic acid mask that restrains the ribonucleolytic activity of ANG. The masked ANG does not stimulate endothelial cell proliferation but protects astrocytes from oxidative stress. By differentiating between the two dichotomous biological activities of ANG, this strategy could provide a viable pharmacological approach for the treatment of ALS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available