Journal
BIOMATERIALS
Volume 120, Issue -, Pages 103-114Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.12.027
Keywords
Gold nanoclusters (GNCs); Gd3+ ions; Assembly; Multi-modality imaging; Diagnosis
Funding
- National Key Basic Research Program (973 Project) [2015CB931802]
- National Natural Scientific Foundation of China [81401458, 81225010, 81028009, 31170961]
- 863 project of China [2014AA020701]
- Shanghai Science and Technology Fund [14ZR1432400, 13NM1401500]
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It is essential to develop a simple synthetic strategy to improve the quality of multifunctional contrast agents for cancer diagnosis. Herein, we report a time-saving method for gadolinium (Gd3+) ions mediated self-assembly of gold nanoclusters (GNCs) into monodisperse spherical nanoparticles (GNCNs) under mild conditions. The monodisperse, regular and colloidal stable GNCNs were formed via selectively inducing electrostatic interactions between negatively-charged carboxylic groups of gold nanoclusters and trivalent cations of gadolinium in aqueous solution. In this way, the Gd3+ ions were chelated into GNCNs without the use of molecular gadolinium chelates. With the co-existence of GNCs and Gd3+ ions, the formed GNCNs exhibit significant luminescence intensity enhancement for near infrared fluorescence (NIRF) imaging, high X-ray attenuation for computed tomography (CT) imaging and reasonable r1 relaxivity for magnetic resonance (MR) imaging. The excellent biocompatibility of the GNCNs was proved both in vitro and in vivo. Meanwhile, the GNCNs also possess unique NIRF/CT/MR imaging ability in A549 tumor-bearing mice. In a nutshell, the simple and safe GNCNs hold great potential for tumor multi-modality clinical diagnosis. (C) 2016 Elsevier Ltd. All rights reserved.
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