Journal
MICROORGANISMS
Volume 5, Issue 1, Pages CP6-U15Publisher
MDPI
DOI: 10.3390/microorganisms5010001
Keywords
Lactic acid bacteria; Peyer's patches; Dendritic cells; T helper cells; Lactobacillus bulgaricus; Streptococcus thermophilus; Interferon gamma; Interleukin 17; Mucosal immunity; Probiotics
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Funding
- Strategic International Collaborative Research Program (SICORP)
- Japan Society for the Promotion Science [15H04504]
- Cross-ministerial Strategic Innovation Promotion Program (SIP)
- Research Program on Hepatitis from Japan Agency for Medical Research and Development (AMED)
- Canon Foundation
- Grants-in-Aid for Scientific Research [15H04504] Funding Source: KAKEN
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Lactic acid bacteria (LAB) form a major component of gut microbiota and are often used as probiotics for fermented foods, such as yoghurt. In this study, we aimed to evaluate immunomodulatory activity of LAB, especially that of Lactobacillus bulgaricus ME-552 (ME552) and Streptococcus thermophilus ME-553 (ME553). In vivo/in vitro assay was performed in order to investigate their effects on T cell function. After oral administration of ME553 to C57BL/6 mice, the amount of both interferon gamma (IFN-gamma) and interleukin 17 (IL-gamma) produced by cluster of differentiation (CD)(4+) T cells from Peyer's patches (PPs) were significantly enhanced. On the other hand, ME552 only up-regulated the production of IL-gamma from PP cells. The extent of induction for IFN-gamma production differed between ME552 and ME553. These results suggest that LAB modulate T cell effector functions and mucosal immunity.
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