Probing hydrazine with a near-infrared fluorescent chemodosimeter

Hydrazine is highly toxic to humans and animals when inhaled or in contact with the skin. It is also a very important chemical used as propellant, metal corrosion inhibitor, pharmaceutical and intermediate. The simple detection of hydrazine in solution and biosystems becomes very important as a consequence of the foregoing applications. Herein, we report a two-photon fluorescent probing method using a NIR fluorescent chemodosimeter, displaying turn-on fluorescence and color change after cleaving an O-acetyl moiety by hydrazine, which exhibits good selectivity and sensitively in solution and living cells. (C) 2016 Elsevier Ltd. All rights reserved.