Journal
ALZHEIMERS & DEMENTIA
Volume 13, Issue 3, Pages 296-311Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2016.09.012
Keywords
Subjective cognitive decline (SDC); Alzheimer's disease; SCD-I; Preclinical; Operationalization; Harmonization
Categories
Funding
- EU Joint Programme-Neurodegenerative Disease Research (JPND)
- National Institute of Health Carlos III (ISCIII) [AC14/00014]
- European Regional Development Fund (ERDF)
- la Caixa Foundation
- LMUexcellent Initiative
- European Commission (ERC) [PCIG12-GA-2012-334259]
- Alzheimer's Forschung Initiative (AFI) [DE-15035]
- AXA Research Fund
- Fondation Universite Pierre et Marie Curie
- Fondation pour la Recherche sur Alzheimer, Paris, France
- program Investissements d'avenir [ANR-10-IAIHU-06]
- US Department of Health and Human Services (DHHS) [AG03051, AG08051]
- National Institute on Aging of the US National Institutes of Health
- Fisher Center for Alzheimer's Research Foundation
- Hagedorn Fund
- Stringer Foundation
- Louis J. Kay and June E. Kay Foundation
- US National Institute on Aging-National Institutes of Health [K23AG038479]
- Stichting Alzheimer Nederland
- Stichting VUmc fonds
- Gieskes-Strijbis fonds
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Introduction: Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. Methods: Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. Results: Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. Discussion: Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are propcised, to enhance comparability and generalizability across studies. (C) 2016 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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