Journal
CLINICAL NEUROPHYSIOLOGY
Volume 128, Issue 3, Pages 424-432Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2016.12.023
Keywords
Repetitive transcranial magnetic; stimulation (rTMS); Resting-state electroencephalography (EEG); Theta-gamma coupling (TGC); Gamma power; Depression
Categories
Funding
- KAKENHI [08105875, 1022138]
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan
- SENSHIN Medical Research Foundation, Japan
- Temerty Centre for Therapeutic Brain Intervention
- Centre for Addiction and Mental Health post-doctoral fellowship
- Brain and Behavior Research Foundation
- Canadian Foundation for Innovation
- Canadian Institutes of Health Research
- Ontario Ministry of Health and Long-Term Care
- Ontario Ministry of Research and Innovation
- US National Institute of Health (NIH)
- W. Garfield Weston Foundation
- Brain and Behaviour Research Foundation
- Centre for Addiction and Mental Health Foundation
- Campbell Family Mental Health Research Institute
- Ontario Mental Health Foundation
- Sepracor Inc
- AstraZeneca
- Eli Lilly
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Objective: We aimed to investigate neuromodulatory effects of high-frequency left dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation (rTMS) on resting-state electroencephalography (EEG) and their clinical and cognitive correlates in patients with depression. Methods: Thirty-one patients diagnosed with depression included in the present study. Resting-state gamma power and theta-gamma coupling (TGC) were calculated before and after a course of rTMS. We explored the relationship among gamma power, TGC, and clinical/cognitive outcomes as measured with the Hamilton Rating Scale for Depression (HAM-D-17), Beck Depression Inventory (BDI), and Wisconsin Card Sorting Test (WCST). Results: Following rTMS, depressed patients demonstrated significant increases of resting gamma power at the F3 and F4 electrode sites and resting TGC at the C3 and T3 electrode sites. Furthermore, the increased gamma power at the F3 electrode site was significantly correlated with improved score on the HAM-D17 and BDI, while the increased TGC at the C3 electrode site was significantly correlated with reduced number of errors on the WCST. Conclusion: Thus, resting-state gamma power and TGC may represent potential biomarkers of depression associated with therapeutic effects of rTMS. Significance: Resting-state EEG may provide potential biomarkers related to therapeutic effects of rTMS. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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