Journal
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
Volume 2, Issue 1, Pages 5-12Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.synbio.2017.02.002
Keywords
Secondary metabolism; Fungi; Biosynthetic gene clusters; Genome mining; Metabolic modeling; Cell factories
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Funding
- European Commission Marie Curie Initial Training Network Quantfung (FP7-People-2013-ITN) [607332]
- Novo Nordisk Foundation
- Knut and Alice Wallenberg Foundation
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The genomic era has revolutionized research on secondary metabolites and bioinformatics methods have in recent years revived the antibiotic discovery process after decades with only few new active molecules being identified. New computational tools are driven by genomics and metabolomics analysis, and enables rapid identification of novel secondary metabolites. To translate this increased discovery rate into industrial exploitation, it is necessary to integrate secondary metabolite pathways in the metabolic engineering process. In this review, we will describe the novel advances in discovery of secondary metabolites produced by filamentous fungi, highlight the utilization of genome-scale metabolic models (GEMs) in the design of fungal cell factories for the production of secondary metabolites and review strategies for optimizing secondary metabolite production through the construction of high yielding platform cell factories. (c) 2017 Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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