Journal
CHEMISTRYOPEN
Volume 6, Issue 2, Pages 211-215Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/open.201600166
Keywords
continuous flow; fine chemical synthesis; heterogeneous catalysis; hydrogenation; nitriles
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Funding
- JSPS
- Global COE Program (The University of Tokyo, MEXT, Japan)
- ACT-C
- Center of Innovation (COI) Program (JST)
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Hydrogenation of nitriles to primary amines with heterogeneous catalysts under liquid-phase continuous-flow conditions is described. Newly developed polysilane/SiO2-supported Pd was found to be an effective catalyst and various nitriles were converted into primary amine salts in almost quantitative yields under mild reaction conditions. Interestingly, a complex mixture was obtained under batch conditions. Lifetime experiments showed that this catalyst remained active for more than 300h (TON10000) without loss of selectivity and no metal leaching from the catalyst occurred. By using this continuous-flow hydrogenation, synthesis of venlafaxine, an antidepressant drug, has been accomplished.
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