Journal
CLINICAL SCIENCE
Volume 131, Issue 5, Pages 369-379Publisher
PORTLAND PRESS LTD
DOI: 10.1042/CS20160618
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Funding
- U.K. Medical Research Council
- Alzheimer's Research U.K. [ARUK-PPG2016A-3]
- Alzheimers Research UK [ARUK-PPG2016A-3] Funding Source: researchfish
- Medical Research Council [1166681] Funding Source: researchfish
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Cerebral small vessel disease (SVD) is a prevalent, neurological disease that significantly increases the risk of stroke and dementia. The main pathological changes are vascular, in the form of lipohyalinosis and arteriosclerosis, and in the white matter (WM), in the form of WM lesions. Despite this, it is unclear to what extent the key cell types involved -the en-dothelial cells (ECs) of the vasculature and the oligodendrocytes of the WM -interact. Here, we describe the work that has so far been carried out suggesting an interaction between ECs and oligodendrocytes in SVD. As these interactions have been studied in more detail in other disease states and in development, we explore these systems and discuss the role these mechanisms may play in SVD.
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