Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 617, Issue -, Pages 94-100Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2016.10.010
Keywords
Thiol; Nrf2; Reactive oxygen species; Electrophile
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Funding
- Finnish Cultural Foundation
- Kymenlaakso Regional Fund
- Academy of Finland
- Sigrid Juselius Foundation
- Finnish Cancer Foundation
- Jane and Aatos Erkko Foundation
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Reactive oxygen species (ROS) and products of their reactions with cellular macromolecules such as unsaturated fatty acids have been implicated to be important regulators of signalling processes via oxidation or allcylation of redox active thiol residues in target proteins. One of key redox-sensitive signalling proteins mediating the response to oxidant stress is Keap1 (Kelch-like erythroid cell-derived protein with CNC homology [ECH]-associated protein 1), which is a negative regulator of transcription factor Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and the central hub for sensing endogenous and environmental oxidative and electrophilic stress. In this review, we provide an overview of the mechanisms by which Keap1 orchestrates the antioxidant response and how the system can be targeted for therapy. (C) 2016 Elsevier Inc. All rights reserved.
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