Journal
BRAIN BEHAVIOR AND IMMUNITY
Volume 61, Issue -, Pages 27-30Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2016.08.012
Keywords
C-reactive protein; Depression; Antidepressants
Categories
Funding
- National Institute of Aging in the United States
- consortium of UK government departments
- Centre for the Development and Evaluation of Complex Interventions for Public Health Improvement, a UKCRC Public Health Research: Centre of Excellence
- British Heart Foundation
- Cancer Research UK
- Economic and Social Research Council [ESRC RES-590-28-0005]
- Medical Research Council
- Welsh Assembly Government
- Wellcome Trust [WT087640MA]
- UK Clinical Research Collaboration
- UK Medical Research Council
- Academy of Finland
- NordForsk
- Nordic Programme on Health and Welfare
- Economic and Social Research Council
- ESRC [ES/M010147/1, ES/J023299/1] Funding Source: UKRI
- MRC [MR/K023233/1, MR/K013351/1] Funding Source: UKRI
- British Heart Foundation [PG/11/63/29011, RG/13/2/30098] Funding Source: researchfish
- Economic and Social Research Council [ES/J023299/1] Funding Source: researchfish
- Medical Research Council [MR/K013351/1, MR/K023233/1, MR/K026992/1] Funding Source: researchfish
- Stroke Association [TSA2008/05] Funding Source: researchfish
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Elevated levels of inflammatory markers, such as C-reactive protein, are well documented in people with depression. Few studies have examined whether the association between inflammation and depression is symptom specific, and differs according to antidepressant treatment. Using data from the English Longitudinal Study of Ageing (N = 5909), cross-sectional analyses revealed a significant dose-response association between C-reactive protein and the symptoms of fatigue (P < 0.001), restless sleep (P = 0.03), low energy (P = 0.02) and feeling depressed (P = 0.04), but not other symptoms. These associations were absent in users of anti-depressant medication. Our findings suggest the C-reactive protein depression association is symptom-specific and modified by antidepressant treatment. (C) 2016 Elsevier Inc. All rights reserved.
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