Journal
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume 137, Issue -, Pages 49-56Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2016.11.016
Keywords
Atrazine; Oxidative stress; Apoptosis; Nrf2 pathway; Quail liver
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Funding
- National Natural Science Foundation of China [31572586]
- Program for New Century Excellent Talents in University [NECT-1207-02]
- Academic Backbone Project of Northeast Agricultural University [15XG16]
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The bioaccumulation and environmental persistence of atrazine (ATZ) poses a severe hazard to animal ecosystem. Quail has strong sensitivity to environmental pollutant, thus it is one of the most important ecological pollution indicator. However, true proof for the effects of ATZ exposure on the liver of quails is lacking. To evaluate the liver injury and the role of Nrf2-mediated defense responses during ATZ exposure, male quails were treated with ATZ (0, 50, 250 and 500 mg/kg) by oral gavage for 45 days. Histopathological and ultrastructural changes, oxidative stress indices, apoptosis-related factors and Nr12 pathway were detected. ATZ caused irreparable mitochondrial damage and destroyed morphophysiological integrity of the quail liver. Lower level ATZ (< 250 mg/kg) activated Nrf2 signaling pathway to protect liver against oxidative stress and apoptosis via enhancing antioxidative activity. Higher level ATZ (> 500 mg/kg) induced oxidative stress and apoptosis through decrease of non-enzymatic antioxidant, antioxidant enzymes and anti-apoptosis factors and increase of apoptosis factors expressions. Taken together, our results suggested that ATZ-induced hepatotoxicity in quails was associated with blocking Nrf2-mediated defense response.
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