Journal
CELL STEM CELL
Volume 20, Issue 3, Pages 360-+Publisher
CELL PRESS
DOI: 10.1016/j.stem.2016.10.020
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Funding
- Marie Curie grant (FP7-PEOPLE-2012-IEF) [332317]
- Marie Curie grant (FP7-PEOPLE-2013-IEF) [626829]
- University of Verona, Italy
- University of Milan, Italy
- GALM (Gruppo Animazione Lesionati Midollari) (Italy)
- La Colonna (Italy)
- CONFAPI (Verona, Italy)
- Erasmus SM Placement Program at the University of Verona [2013-1-IT2-ERA02-53037]
- EC-FP7 grant [280778 - MERIDIAN]
- Belgian Science Policy grant [IUAP P7/20]
- Flemish Government [METH/07/05]
- Leuven University Fund - Opening the Future grant
- FWO [G.0765.10]
- Foundation Leducq Transatlantic Network (ARTEMIS)
- ERC advanced research grant [EU-ERC269073]
- German Cancer Research Center
- German Research Foundation (DFG) [SFB-873]
- University of Verona [DDSP-FUR-6616]
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Whether new neurons are added in the postnatal cerebral cortex is still debated. Here, we report that the meninges of perinatal mice contain a population of neurogenic progenitors formed during embryonic development that migrate to the caudal cortex and differentiate into Satb2(+) neurons in cortical layers II-IV. The resulting neurons are electrically functional and integrated into local microcircuits. Single-cell RNA sequencing identified meningeal cells with distinct transcriptome signatures characteristic of (1) neurogenic radial glia-like cells (resembling neural stem cells in the SVZ), (2) neuronal cells, and (3) a cell type with an intermediate phenotype, possibly representing radial glia-like meningeal cells differentiating to neuronal cells. Thus, we have identified a pool of embryonically derived radial glia-like cells present in the meninges that migrate and differentiate into functional neurons in the neonatal cerebral cortex.
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