Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 484, Issue 2, Pages 318-322Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2017.01.112
Keywords
Au; Nanorod; Silica; Core-shell; Sol-gel; Photothermal conversion
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [2306]
- JSPS KAKENHI [24310085, 16H05168, 161K15572]
- A3 Foresight Program from JSPS
- Grants-in-Aid for Scientific Research [16H05168, 16K05931] Funding Source: KAKEN
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This study described the preparation of silica-coated Au nanorods (AuNR/SiO2) in a colloidal solution, assessed their property of photothermal conversion, and investigated their ability to kill cancer cells using photothermal conversion. Au-seed nanoparticles were produced by reducing hydrogen tetrachloroaurate (HAuCl4) with sodium borohydride (NaBH4) in aqueous n-hexadecyltrimethylammonium bromide (CTAB) solution. AuNRs were then fabricated by reducing HAuCl4 and silver nitrate (AgNO3) with L-ascorbic acid in the aqueous CTAB solution in the presence of Au-seed nanoparticles. The as prepared AuNRs were washed by a process composed mainly of centrifugation to remove the CTAB. The washed AuNRs were coated with silica by mixing the AuNR colloidal solution, an aqueous solution of (3-aminopropyl)trimethoxysilane, and tetraethylorthosilicate/ethanol solution with a water/ethanol solution. We found that the addition of AuNR/SiO2 in water, in mice, and in a culture medium with cancer cells, followed by irradiation with a laser, cause an increase in temperature, demonstrating that AuNR/ SiO2 have the ability of photothermal conversion. In addition, the cancer cells in the culture medium were found to be killed due to the increase in temperature caused by the photothermal conversion. (C) 2017 Elsevier Inc. All rights reserved.
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