Journal
ANALYTICAL CHEMISTRY
Volume 89, Issue 5, Pages 2704-2707Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.6b05049
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21327008]
- Gordon and Betty Moore Foundation
Ask authors/readers for more resources
Surface plasmon resonance microscopy (SPRM) is a powerful platform for biomedical imaging and molecular binding kinetics analysis. However, the spatial resolution of SPRM along the plasmon propagation direction (longitudinal) is determined by the decaying length of the plasmonic wave, which can be as large as tens of microns. Different methods have been proposed to improve the spatial resolution, but each at the expense of decreased sensitivity or temporal resolution. Here we present a method to achieve high spatial resolution SPRM based on deconvolution of complex field. The method does not require additional optical setup and improves the spatial resolution in the longitudinal direction. We applied the method to image nanoparticles and achieved close-to-diffraction limit resolution in both longitudinal and transverse directions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available