Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 755, Issue -, Pages 34-41Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2015.02.047
Keywords
Regulation; Nicotinic acetylcholine receptors; Alzheimer; Chaperone
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Nicotinic acetylcholine receptors (nAChRs) seem to play an integral role in the progress and/or prevention of Alzheimer's diseases (AD). Functional abnormalities and problems in biogenesis and trafficking of nAChRs are two major culprits in AD; on the other hand, chaperones modulate post-translational changes in nAChRs. Moreover, they indirectly regulate nAChRs by controlling AD-related proteins such as tau and amyloid beta (A beta). In this review, we go through recent studies which are showing that chaperones modulate the expression of nAChRs in a subtype-specific manner and explain how AD progress is affected by nAChRs chaperoning. (C) 2015 Elsevier B.V. All rights reserved.
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